Ebastine is a newer second-generation H1 blocker that gets converted quickly to the active metabolite carebastine, with a t½ of 10–14 hours. It is non-sedating and effective for nasal and skin allergies. It has been shown in animal studies to prolong Q-Tc interval, making it liable to arrhythmogenic potential and CYP3A4 interaction, however there are […]
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Azelastine is a newer H1 blocker, has good topical activity and additionally suppresses histamine release and inflammatory reactions caused by LTs (by inhibiting lipoxygenase) and PAF. It has been demonstrated to reduce intracellular adhesion molecule-1 (ICAM-1) expression on nasal mucosa after intranasal administration. It has a t½ of 24 hours, however due to the active
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Pheniramine (most famous brand name ‘Avil’) is an H1 antihistamine, used to treat acute allergic conditions such as insect bite/sting, drug allergy, blood transfusion reaction etc. it is moderately sedative and produces other CNS side effects, as crosses blood-brain barrier. Drug class H1 antihistamine, 1st generation Available preparations pheniramine maleate Tablet: 25 mg, 50 mg
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Levocetirizine is an H1 antihistamine that is used to treat a variety of allergic conditions. It is the active R-enantiomer of cetirizine. Levocetirizine do not cross blood-brain barrier. As compared to cetirizine, it is effective at half the dose and appears to cause less sedation and lack of anticholinergic side effects. Cetirizine and levocetirizine have
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Cetirizine is an H1 antihistamine that is used to treat a variety of allergic conditions. It is a metabolite of hydroxyzine with high affinity for peripheral H1 receptors. Cetirizine in addition inhibits release of histamine and of cytotoxic mediators from platelets as well as eosinophil chemotaxis during the secondary phase of the allergic response. Thus,
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