Recent Advances

antiemetics mechanism and classification

Antiemetics: classification, mechanism and uses/ etiology-based drug selection

Drugs and Diseases, Recent Advances

Antiemetics are drugs used to prevent vomiting. Vomiting is a protective mechanism of GIT/stomach to expel out undesired or hazardous foods or chemicals. It is an innate protective reflex rather than a disease, while nausea is the sense of vomiting. Sometime undesirable vomiting can occur due to emotional stress, motion sickness, therapeutic drugs like anticancer, […]

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Deflazacort: dose, uses, side effects and properties

Leave a Comment / Drugs and Diseases, Recent Advances

Deflazacort is a synthetic glucocorticoid, with anti-inflammatory and immunomodulating properties. It is a prodrug, converts to active metabolite by plasma esterases. It has approved by the FDA to manage Duchenne Muscular Dystrophy (DMD). With less adverse effects on bone health and weight than other steroids, it improves the lives of children with DMD by delaying

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chronobiology image

Chronopharmacology: the effect of drugs upon timing.

Recent Advances

It is a field in which drug administration is synchronized with the biological rhythm in order to optimize the therapeutic effect while minimizing side effects. A collective knowledge of variation in disease intensity and exacerbation, impact of circadian rhythm on the efficacy and safety of medication constitutes the rationale for a novel pharmacological approach.

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hybridoma technique flowchart

Hybridoma technique: procedure and advancement

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Hybridoma technique is the most favored and efficient method for exploring and producing  monoclonal antibodies (mAbs). At present, The majority of the mAbs approved by the US-FDA are manufactured utilizing hybridoma technique. It is introduced by Kohler and Milstein in 1975 and got the Nobel prize in 1984. OKT3 (muromonantibody) against CD-3 is the first

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Immunotoxins: structure, mechanism, uses and limitations

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Immunotoxins are a new class of large molecules and targeted anticancer drugs. It is a conjugated protein containing an antibody, growth factor, or cytokine that binds directly to target cells and toxins (e.g. Diphtheria toxin) joined together with a pH-sensitive cross linker that serves as a disulfide bond in between. Like “magic bullets,” it destroys

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