Ebastine: dose, uses, side effects and properties

Ebastine is a newer second-generation H1 blocker that gets converted quickly to the active metabolite carebastine, with a t½ of 10–14 hours. It is non-sedating and effective for nasal and skin allergies. It has been shown in animal studies to prolong Q-Tc interval, making it liable to arrhythmogenic potential and CYP3A4 interaction, however there are few actual reports.

Drug class

H1 antihistamine, 2nd generation

Available preparations


  • Tablet: 10 mg, 20 mg
  • Syrup: 5 mg/5 ml


  • Adult: 10-20 mg once daily
  • Children: 5 mg once daily (not recommended below 6-year age)

Common uses

  • Seasonal and perennial allergic rhinitis
  • Chronic idiopathic urticaria

Side effects

  • Animal studies have found it to prolong Q-Tc interval
  • Mild headedness
  • Nausea

Pharmacological characteristics

  • Onset of action: 1-3 hours
  • Duration of action: 24-28 hours
  • Half-life (t1/2): 10-14 hours
  • Metabolized by CYP 3A4 to active metabolite carebastine, hence metabolism inhibited by CYP 3A4 inhibitors
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