Introduction Pharmacokinetic is the kinesis (movement) of pharmacological substances (drugs) throughout the body, which includes all phases and processes from entering to leaving the body. It is merely “what the body does with the drug.” Those drug kinetics can be broadly divided into 4 (ADME): If the drug is administered intravenously, there are only three […]
Daridorexant (nemorexant) is a newer class of sedative-hypnotic drugs under non-benzodiazepine category. it is used to treat insomnia in adults. daridorexant blocks binding of wake promoting neuropeptides (orexin A and orexin B) to its receptors OX-1 and OX-2. It should be avoided in patients with depression. Drug class Orexin receptor antagonist, hypnotics Available preparation Daridorexant
Daridorexant: dose, uses and side effects Read More »
Prodrugs are described as inactive drugs that must be changed into one or more active metabolites within the body in order to exert the desired pharmacological effect. The prodrug may be more stable, have greater bioavailability, or other desired pharmacokinetic features, or have fewer side effects and toxicity than the active form. Some prodrugs are
Prodrugs: list, types, objectives and methods of prodrug designing Read More »
CYP 3A4/5 is the most abundant microsomal enzyme (CYP) and conducts biotransformation of the majority (almost 50%) of drugs. The pace of metabolism is increased by 2–4 fold by the induction of microsomal enzymes (CYP450). Induction takes 4–14 days to reach its peak and is maintained till the inducing agent is being given. The enzymes
CYP enzymes: substrates, inducers and inhibitors Read More »
