CYP enzymes: substrates, inducers and inhibitors
CYP 3A4/5 is the most abundant microsomal enzyme (CYP) and conducts biotransformation of the majority (almost 50%) of drugs. The pace of metabolism is increased by 2–4 fold by the induction of microsomal enzymes (CYP450). Induction takes 4–14 days to reach its peak and is maintained till the inducing agent is being given. The enzymes […]
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